High Intensity Training for Men with Prostate Cancer on Active Surveillance: A proposal

Full Name: Efthymios Papadopoulos

Academic Affiliation: Faculty of Kinesiology and Physical Education, University of Toronto

Position: PhD student, MSc, R.Kin

Abstract: Introduction: Physical exercise appears to be an effective strategy for ameliorating physiological and psychosocial adverse events in men with prostate cancer (PCa). Compelling evidence suggests that exercise displays numerous anticarcinogenic effects while enhancing quality of life (QOL) in this population across the continuum of cancer care. Furthermore, it has been demonstrated that exercising at higher intensities appears to provide additional benefits to clinical outcomes and QOL in men with PCa. The majority of the literature has been primarily focused on the effects of exercise in men undergoing active treatment while very little information exists regarding the effects of an exercise intervention in those electing active surveillance (AS). The aim of this pilot randomized controlled trial is to examine the effects of a six months high-intensity interval training (HIIT) and resistance training (RES) intervention on cancer-related biomarkers and psychosocial outcomes in men with PCa undergoing AS. Methods: Sixty men with PCa undergoing AS will be recruited and randomized to intervention or control groups (CG) following screening. The intervention groups (IG) will undergo vigorous aerobic or resistance training for 24 weeks while the CG will receive usual care. Clinical, physical, and psychosocial outcomes will be assessed at baseline and throughout the intervention period. We hypothesize that IG participants will experience a healthier blood biomarker profile, an improved QOL and less fear of disease progression compared to CG.